Crizalk also known as Xalkori (Crizotinib) in other parts of the world is is a prescription drug manufactured by Pfizer used to treat non-small cell lung cancer (NSCLC) that is advanced or has spread to other parts of the body and is caused by a defect in a gene called ALK (anaplastic lymphoma kinase). It is Available in 200 mg dosage & 60 capsule pack.
- bifunctional alkylating agent
XALKORI may cause serious side effects, some of which may include:
Liver problems : Crizalk (Xalkori) may cause life-threatening and/or fatal liver injury. Your doctor should do blood tests every month to check your liver while you are taking XALKORI. Tell your doctor right away if you get any of the following:
- your skin or the whites of your eyes turn yellow
- you feel tired
- your urine turns dark or brown (tea color)
- you have nausea or vomiting
- you have a decreased appetite
- you have pain on the right side of your stomach
- you bleed or bruise more easily than normal
- you have itching
Swelling of the lungs (pneumonitis) — XALKORI may cause life-threatening and/or fatal swelling (inflammation) of the lungs during treatment. Symptoms may be similar to those symptoms from lung cancer. Tell your doctor right away if you have any new or worsening symptoms, including:
trouble breathing or shortness of breath
cough with or without mucous
Changes in heartbeat (called QT interval prolongation), very fast or abnormal heartbeats — Your doctor may check your heart during treatment with XALKORI. Tell your doctor right away if you have abnormal heartbeats, feel dizzy, or faint. These may be symptoms related to QT interval prolongation.
Before you take XALKORI, tell your doctor if you:
have heart problems, including a condition called long QT syndrome
have liver or kidney problems
have any other medical conditions
are pregnant, or plan to become pregnant. XALKORI may harm your unborn baby.
Women who are able to become pregnant and men who take XALKORI should use birth control during treatment and for 3 months after stopping XALKORI.
Talk to your doctor about the birth control methods that may be right for you.
If you or your partner becomes pregnant, tell your doctor right away.
are breastfeeding or plan to breastfeed. It is not known if XALKORI® (crizotinib) passes into your breast milk. You and your doctor should decide if you will take XALKORI or breastfeed. You should not do both.
Especially tell your doctor if you take:
St. John’s Wort (Hypericum perforatum)
- depression (antidepressants)
- fungal infections (antifungals)
- bacterial infections (antibiotics)
- tuberculosis (TB)
- heart conditions
Know the medicines you take. Keep a list of them to show your doctor or pharmacist when you get a new medicine.
Do not drink grapefruit juice or eat grapefruit during treatment with XALKORI. It may increase the amount of XALKORI in your blood to a harmful level.
The most common side effects of XALKORI include:
- vision problems — these problems usually happen within 2 weeks of starting XALKORI. Tell your doctor right away if you have any change in vision, such as:
- flashes of light
- blurred vision
- light hurting your eyes
- new or increased floaters
- swelling of your hands or feet
Use caution when driving or operating machinery as XALKORI may cause changes in vision or make you feel tired or dizzy.